Which factor is associated with an increased risk of primary CNS lymphoma?

Which factor is associated with an increased risk of primary CNS lymphoma?

• A. Young age under 20
• B. Weakened immune system (HIV)
• C. High-fat diet
• D. Athletic training

Answer: (B)

A weakened immune system is a major risk factor for primary CNS lymphoma. When immune surveillance, especially cell-mediated immunity, is compromised—as in HIV infection—the body has a harder time controlling abnormal B-cell growth in the brain. In HIV-associated CNS lymphoma, the malignant cells are often driven by Epstein-Barr virus, taking advantage of reduced immune control. This makes HIV and similar states of immunosuppression strongly linked to increased risk. The other options—young age, high-fat diet, and athletic training—do not have established associations with primary CNS lymphoma.

A weakened immune system is a major risk factor for primary CNS lymphoma. When immune surveillance, especially cell-mediated immunity, is compromised—as in HIV infection—the body has a harder time controlling abnormal B-cell growth in the brain. In HIV-associated CNS lymphoma, the malignant cells are often driven by Epstein-Barr virus, taking advantage of reduced immune control. This makes HIV and similar states of immunosuppression strongly linked to increased risk. The other options—young age, high-fat diet, and athletic training—do not have established associations with primary CNS lymphoma.